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Luke Charteris and Rhys Priestland will also feature from the start for the Blue, Black and White.
Charteris will partner Elliott Stooke in the second row, Tom Dunn will be at hooker while Kane Palma-Newport and Nick Auterac are deployed either side.
Director of Rugby Todd Blackadder said: "We are really excited about the next couple of European games we have coming up - it is a different competition, and that gives us a chance to have a fresh look at things.
"We have not made too many changes but it is a fantastic opportunity for the guys who have not had as much game time as some to step up and start for us.
"It is great to have the likes of Guy Mercer, Luke Charteris and Rhys Priestland back. All three are experienced players who will give us a new energy going into the game."
Bath team vs Pau in full:
15. Tom Homer
14. Semesa Rokoduguni
13. Jonathan Joseph
12. Matt Banahan
11. Aled Brew
10. Rhys Priestland
9. Kahn Foutali'i
1. Nick Auterac
2. Tom Dunn
3. Kane Palma-Newport
4. Luke Charteris
5. Elliott Stooke
6. Tom Ellis
7. Guy Mercer (c)
8. Leroy Houston
Replacements:
16. Michael van Vuuren
17. Max Lahiff
18. Shaun Knight
19. Charlie Ewels
20. Matt Garvey
21. Chris Cook
22. Dan Bowden
23. Jeff Williams
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